Serum and Urine Concentrations of Flunitrazepam and Metabolites, after a Single Oral Dose, by Immunoassay and GC-MS

A clinical study was conducted to assess the ability of commercially available immunoassays to detect flunitrazepam (FNP) in plasma and urine samples and to compare the results with those obtained by gas chromatography-mass spectrometry (GC-MS). The clinical study consisted of four individuals (two male and two female) who had taken a single 2-mg dose of FNP. Serum was collected over a 48-h period and urine was collected over a 72-h period. The serum and urine samples were analyzed by the COBAS® INTEGRA Serum Benzodiazepines assay (SBENZ), the TDx serum and urine Benzodiazepines assay, and GC-MS. The GC-MS procedure was developed for analysis of FNP and metabolites in plasma and urine using an acid hydrolysis step resulting in the formation of specific benzophenones corresponding to FNP and its metabolites. The relative sensitivities of the assays for the detection of FNP and metabolites in serum and urine were GC-MS > SBFNZ > TDx. The immunoassay results for serum samples showed peak concentrations of FNP metabolites at 8 h after FNP ingestion for three individuals and at about 1 h for the fourth individual. The GC-MS, SBENZ, and TDx urine immunoassays detected drug above the stated limit of detection (LOD) in 44, 41, and 35 serial FNP urine samples, respectively. FNP metabolites were detected in urine samples with all three assays for up to 72 h after a 2-mg dose. The improved detection rate with the SBENZ assay as compared to the TDx assay is likely explained by its higher cross-reactivity with the major metabolite, 7-amino-flunitrazepam (7-amino-FNP), and its lower LO

The precision of today's satellite laser ranging systems

Recent improvements in the accuracy of modern satellite laser ranging (SLR) systems are strengthened by the new capability of many instruments to track an increasing number of geodetic satellite targets without significant scheduling conflict. This will allow the refinement of some geophysical parameters, such as solid Earth tidal effects and GM, and the improved temporal resolution of others, such as Earth orientation and station position. Better time resolution for the locations of fixed observatories will allow us to monitor more subtle motions at the stations, and transportable systems will be able to provide indicators of long term trends with shorter occupations. If we are to take advantage of these improvements, care must be taken to preserve the essential accuracy of an increasing volume of range observations at each stage of the data reduction process

Infrared Imaging of Capella with the IOTA Closure Phase Interferometer

We present infrared aperture synthesis maps produced with the upgraded IOTA interferometer. Michelson interferograms on the close binary system Capella (Alpha Aur) were obtained in the H-band between 2002 November 12 and 16 using the IONIC3 beam combiner. With baselines of 15m < B < 38m, we were able to determine the relative position of the binary components with milliarcsecond (mas) precision and to track their movement along the approx. 14 degree arc covered by our observation run. We briefly describe the algorithms used for visibility and closure phase estimation. Three different Hybrid Mapping and Bispectrum Fitting techniques were implemented within one software framework and used to reconstruct the source brightness distribution. By dividing our data into subsets, the system could be mapped at three epochs, revealing the motion of the stars. The precise position of the binary components was also determined with model fits, which in addition revealed I_Aa/I_Ab=1.49 +/- 0.10 and apparent stellar uniform-disk (UD) diameters of Theta_Aa=8.9 +/- 0.6 mas and Theta_Ab=5.8 +/- 0.8 mas. To improve the u, v-plane coverage, we compensated this orbital motion by applying a rotation-compensating coordinate transformation. The resulting model-independent map with a beam size of 5.4 x 2.6 mas allows the resolution of the stellar surfaces of the Capella giants themselves.Comment: Accepted by the Astronomical Journal (2005-03-21

A meteorological report for the Mount Hopkins Observatory - 1968 - 1969

Meteorological data for Mt. Hopkins Observatory for 1968 and 196

Beings in their own right? Exploring Children and young people's sibling and twin relationships in the Minority World

This paper examines the contributions that the sociological study of sibship and twinship in the Minority World can make to childhood studies. It argues that, in providing one forum within which to explore children and young people's social relationships, we can add to our understanding of children and young people's interdependence and develop a more nuanced understanding of agency. As emergent subjects, children, young people and adults are in a process of ‘becoming’. However, this does not mean that they can ‘become’ anything they choose to. The notion of negotiated interdependence (Punch 2002) is useful in helping us to grasp the contingent nature of children and young people's agency

Third telescope project at the IOTA interferometer

The third telescope project to enable phase-closure observations at the IOTA interferometer is well underway, and is anticipated to be completed later this year. For this project, we present the main technical improvements which we have already made or expect to make, including a new VxWorks control system, improved star acquisition cameras, improved siderostat and primary mirror supports, five-axis control of the telescope secondary mirrors, automated control of the long delay line, trihedral retroreflectors, three-beam combination, the PICNIC camera, and fringe packet tracking

Negative parental responses to coming out and family functioning in a sample of lesbian and gay young adults

Parental responses to youths' coming out (CO) are crucial to the subsequent adjustment of children and family. The present study investigated the negative parental reaction to the disclosure of same-sex attraction and the differences between maternal and paternal responses, as reported by their homosexual daughters and sons. Participants' perceptions of their parents' reactions (evaluated through the Perceived Parental Reactions Scale, PPRS), age at coming out, gender, parental political orientation, and religiosity involvement, the family functioning (assessed through the Family Adaptability and Cohesion Evaluation Scales, FACES IV), were assessed in 164 Italian gay and lesbian young adults. Pearson correlation coefficients were calculated to assess the relation between family functioning and parental reaction to CO. The paired sample t-test was used to compare mothers and fathers' scores on the PPRS. Hierarchical multiple regression was conducted to analyze the relevance of each variable. No differences were found between mothers and fathers in their reaction to the disclosure. The analysis showed that a negative reaction to coming out was predicted by parents' right-wing political conservatism, strong religious beliefs, and higher scores in the scales Rigid and Enmeshed. Findings confirm that a negative parental reaction is the result of poor family resources to face a stressful situation and a strong belief in traditional values. These results have important implications in both clinical and social fields

Representations of sport in the revolutionary socialist press in Britain, 1988–2012

This paper considers how sport presents a dualism to those on the far left of the political spectrum. A long-standing, passionate debate has existed on the contradictory role played by sport, polarised between those who reject it as a bourgeois capitalist plague and those who argue for its reclamation and reformation. A case study is offered of a political party that has consistently used revolutionary Marxism as the basis for its activity and how this party, the largest in Britain, addresses sport in its publications. The study draws on empirical data to illustrate this debate by reporting findings from three socialist publications. When sport did feature it was often in relation to high profile sporting events with a critical tone adopted and typically focused on issues of commodification, exploitation and alienation of athletes and supporters. However, readers’ letters, printed in the same publications, revealed how this interpretation was not universally accepted, thus illustrating the contradictory nature of sport for those on the far left